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Information for Patients & Caregivers
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Taking KUVAN

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How to Start

  1. Get Organized

    Lowering Phe and feeling better is in your grasp. First, get organized to talk to a doctor and find a clinic.

  2. Find & Visit a PKU Clinic

    Regular visits to a PKU clinic are important. Think of the clinic as your partner in helping you manage PKU. Here, you can locate a clinic and find out what to expect when you visit.

  3. Test for Responsiveness to KUVAN

    It is not possible to know whether KUVAN will work until you start taking KUVAN.12 These are the steps you and your doctor will take to determine whether KUVAN works for you.

  4. Try KUVAN free

    Take advantage of a FREE 30-day trial of KUVAN and find out if you respond. It may be your key to lower Phe.

  5. How to Take KUVAN

    KUVAN tablets are easy to take. Here’s how simple it is.

  6. Become a KUVAN.com Member

    With membership, you gain access to a Web-based application where you can easily track your diet and Phe intake, KUVAN medication, Phe levels, doctor appointments, and more.

  7. Register for Updates

    Sign up to get the latest news about KUVAN and KUVAN.com updates.

  8. Order KUVAN from a Specialty Pharmacy

    After you find you respond to the 30-day trial of KUVAN, order the medicine from a specialty pharmacy and have it delivered to your home.

  9. Help with Insurance & Financial Assistance

    Take advantage of BPPS to make it easier to go through the insurance process—from investigating your prescription benefits, and identifying additional insurance, to submitting the required paperwork.

  10. Find a PKU Friend

    Find your support system. Find a friend in the PKU.com community or listen to personal stories.
Talk to Your Doctor

Indication

KUVAN® (sapropterin dihydrochloride) Tablets are approved to reduce blood Phe levels in patients with hyperphenylalaninemia (HPA) due to tetrahydrobiopterin- (BH4-) responsive Phenylketonuria (PKU). KUVAN is to be used in conjunction with a low-Phe diet.

Important Safety Information

High blood Phe levels are toxic to the brain and can lead to lower intelligence and decrease in the ability to focus, remember and organize information. Any change you make to your diet may impact your blood Phe level. Follow your doctor's instructions carefully. Your doctor and dietitian will continue to monitor your diet and blood Phe levels throughout your treatment with KUVAN.

If you have a fever, or if you are sick, your Phe level may go up. Tell your doctor and dietitian as soon as possible so they can see if they have to adjust your treatment to help keep your blood Phe levels in the desired range.

KUVAN is a prescription medicine and should not be taken by people who are allergic to any of its ingredients. Tell your doctor if you have ever had liver or kidney problems, are nursing or pregnant or may become pregnant, have poor nutrition or are anorexic. Your doctor will decide if KUVAN is right for you. Tell your doctor about all the medicines you take.

The most common side effects reported when using KUVAN are headache, diarrhea, abdominal pain, upper respiratory tract infection (like a cold), throat pain, vomiting, and nausea.

To report SUSPECTED ADVERSE REACTIONS, contact BioMarin Pharmaceutical Inc. at 1-866-906-6100, or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please read the full Patient Information by clicking here.


This site is intended for use by U.S. residents only.

KUVAN® is a registered trademark of BioMarin Pharmaceutical Inc. Developed in collaboration with Asubio Pharma Co., Ltd.
©2010 BioMarin Pharmaceutical Inc. All rights reserved.