KUVAN® (sapropterin dihydrochloride) Tablets or Powder for Oral Solution Materials
What is KUVAN
Learn about what KUVAN is and how it can be a part of PKU treatment Download PDF
How KUVAN Works
See how KUVAN works in the body to help lower blood Phe levels Download PDF
KUVAN Powder 500 mg
KUVAN Powder is now available in a 500 mg packet – learn about the benefits of this convenient option! Download PDF
How to Take KUVAN Powder
Learn how easy it is to take your dose of KUVAN Powder in 3 simple steps Download PDF
KUVAN Powder FAQ
Answers to some of the most frequently asked questions about KUVAN Powder Download PDF
How to Take KUVAN Tablets
A quick guide to taking KUVAN Tablets, including things to keep in mind during your treatment with KUVAN Download PDF
KUVAN Parent Flyer
Learn about KUVAN, and how it may be able to help manage your child’s PKU Download PDF
Insurance and Financial Support Materials
Introduction to BioMarin RareConnections™
Learn about the BioMarin RareConnections™ team, and how they can support you in seeking access to KUVAN Download PDF
Introduction to the National Organization for Rare Disorders (NORD)
Read about what NORD is, and what programs they offer to support individuals with PKU Download PDF
Visit PKU.com for more helpful tools about PKU management!
KUVAN® (sapropterin dihydrochloride) Tablets for Oral Use and Powder for Oral Solution are approved to reduce blood Phe levels in people with a certain type of Phenylketonuria (PKU). KUVAN is to be used with a Phe-restricted diet.
Important Safety Information
It is not possible to know if KUVAN will work for you without a trial of the medicine. Your doctor will check your blood Phe levels when you start taking KUVAN to see if the medicine is working.
Starting KUVAN does not eliminate the need for ongoing dietary management. Any change to your diet may impact your blood Phe level. Follow your doctor’s instructions carefully. Your doctor and dietitian will continue to monitor your diet and blood Phe levels throughout your treatment with KUVAN to make sure your blood Phe levels are not too high or too low. If you have a fever, or if you are sick, your Phe level may go up. Tell your doctor and dietitian as soon as possible so they can make any necessary changes to your treatment.
Children younger than 7 years old treated with KUVAN doses of 20 mg/kg per day are at an increased risk for low levels of blood Phe compared with children 7 years and older. Frequent blood monitoring is recommended in this population to ensure that blood Phe levels do not fall too low.
Tell your doctor if you have ever had liver or kidney problems, have poor nutrition or have a loss of appetite, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.
KUVAN is a prescription medicine and should not be taken by people who are allergic to any of its ingredients. KUVAN and other medicines may interact with each other. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal and dietary supplements.
If you forget to take your dose of KUVAN, take it as soon as you remember that day. Do not take 2 doses in a day. If you take too much KUVAN, call your doctor for advice.
The most common side effects reported when using KUVAN are headache, runny nose and nasal congestion, sore throat, diarrhea, vomiting, and cough. Additional adverse reactions reported in connection with worldwide marketing include sore throat, heartburn or pain in the esophagus, inflammation of the lining of the stomach, indigestion, stomach pain, nausea, and nose irritation. These are not all the possible side effects seen with KUVAN. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
KUVAN can cause serious side effects, including:
Severe allergic reactions. Stop taking KUVAN and get medical help right away if you develop any of these symptoms of a severe allergic reaction:
Wheezing or trouble breathing
Lightheadedness or fainting
Inflammation of the lining of the stomach (gastritis). Gastritis can happen with KUVAN and may be severe. Call your doctor right away if you have any:
Severe upper stomach-area discomfort or pain
Blood in your vomit or stool
Nausea and vomiting
Black, tarry stools
Too much or constant activity (hyperactivity) can happen with KUVAN. Tell your doctor if you have any signs of hyperactivity, including fidgeting, moving around or talking too much.
For more information, call BioMarin RareConnections™ at 1-877-MY-KUVAN (1-877-695-8826).
Please read the full Patient Information by clicking here.